Name some heritable forms of leukoderma. - Albinism is a group of autosomal recessive disorders characterized by generalized depigmented or hypopigmented skin and decreased visual acuity and nystagmus secondary to alterations in the formation of melanin.
- Waardenburg’s syndrome is an autosomal dominant disorder associated with congenital deafness, heterochromic irides, amelanotic skin macules, white forelock, laterally displaced medial canthi, and widening of the nasal root.
- Hermansky-Pudlak syndrome is rare autosomal recessive disorder in which affected individuals suffer from generalized hypopigmentation, excessive bleeding due to platelet abnormalities, and lysosomal defects leading to ceroid accumulation in most body tissues.
Dessinioti C, Stratigos AJ, Rigopoulous D, Katsambas AD: A review of genetic disorders of hypopigmentation: lessons learned from the biology of melanocytes, Exp Dermatol 18:741–749, 2009. |
