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Autoimmune Connective Tissue Diseases

»	Discuss the skin changes of lupus erythematosus.
»	What is acute cutaneous lupus erythematosus (ACLE)?
»	Are there any common skin eruptions that may be confused with acute cutaneous lupus erythematosus?
»	What is subacute cutaneous lupus erythematosus (SCLE)?
»	Do patients with SCLE have SLE?
»	How do you make a diagnosis of SCLE?
»	What is the initial workup of SCLE?
»	How is SCLE managed?
»	What is chronic cutaneous lupus erythematosus?
»	Describe the skin changes of discoid lupus erythematosus.
»	Do patients with DLE develop systemic lupus erythematosus?
»	How is discoid lupus erythematosus treated?
»	What is minocycline-induced lupus?
»	What is lupus panniculitis?
»	Describe the bullous eruption of SLE.
»	How is the bullous eruption of systemic lupus erythematosus treated?
»	What is neonatal lupus erythematosus (NLE)?
»	Which tests should be done in an infant with suspected NLE?
»	Once a diagnosis of NLE is made, what workup should be done?
»	What is the lupus band test?
»	What is scleroderma?
»	What is the CREST syndrome?
»	Describe the early cutaneousfindings in progressive systemic sclerosis (PSS).
»	What is dermatomyositis?
»	Are there skin changes diagnostic of dermatomyositis?
»	How do you diagnose dermatomyositis?
»	Are any diseases associated with dermatomyositis?
»	What is the antisynthetase syndrome?
»	What is an overlap syndrome?
»	What is mixed connective tissue disease?
»	What is the antiphospholipid antibody syndrome?
»	What are some other connective tissue diseases with cutaneous manifestations?
»	What autoantibodies are associated with the different autoimmune connective tissue diseases?

What autoantibodies are associated with the different autoimmune connective tissue diseases?

See Tables 22-4, 22-5, and 22-6.

Sheldon J: Laboratory testing in autoimmune rheumatic diseases, Best Pract Res Clin Rheumatol 18:249–269, 2004.

D’Cruz, D: Testing for autoimmunity in humans, Toxicol Lett 127: 93–100, 2002.