What is the initial workup of SCLE? Once a diagnosis of SCLE is made, it is important to evaluate for the presence of SLE: - History and physical examination data should be gathered to identify manifestations of SLE in other organ systems.
- Laboratory testing should be directed by findings on the history and physical exam but will generally include a complete blood count with differential, urinalysis, serum chemistries including renal function tests, and an ANA panel to include anti–Ro/SS-A, anti–La/SS-B, and anti–native DNA antibodies. Complement determinations may be ordered since some SCLE patients have partial or complete complement deficiencies.
- A medication history is very important since SCLE may be triggered or worsened by a number of medications, especially thiazide diuretics (Table 22-2). Some physicians recommend avoiding estrogens and sulfonamides in any patient with LE.
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