Describe the clinical lesions in scleredema and its disease associations. Scleredema presents as a firm, woody induration of the skin typically involving the upper trunk, posterior neck, and shoulders. Histologically, it is characterized by an accumulation of dermal mucin and increased sclerosis of dermal collagen. Scleredema may be seen in several different clinical settings, including postinfection, in association with diabetes mellitus, and in the setting of paraproteinemia. Boin F, Hummers LK: Scleroderma-like fibrosing disorders, Rheum Dis Clin North Am 34:199–220, 2008. |
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