What are the systemic manifestations of secondary systemic amyloidosis?

Organs commonly involved in secondary systemic amyloidosis include the liver, spleen, and kidneys, resulting in hepatosplenomegaly and nephrotic syndrome, respectively. Although skin lesions are generally lacking, biopsy of subcutaneous abdominal fat may demonstrate amyloid deposition.

Hazenberg BP, Bijzet J, Limburg PC, et al: Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis, Amyloid 14:133–140, 2007.

Lachmann HJ, Goodman HJ, Gilbertson JA, et al: Natural history and outcome in systemic AA amyloidosis, N Engl J Med 356:2361–2371, 2007.