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| Fig. 16.4 A, Pretibial myxedema. Thick plaques on anterior lower legs with peau d’orange change secondary to dermal mucin. B, Digital mucous cyst. Domeshaped cystic nodule overlying the distal interphalangeal joint. |
Patients with pretibial myxedema develop nodules or diffuse plaques usually on the anterior lower legs, although involvement of other sites has been rarely reported (Fig. 16-4A). The lesions result from large amounts of dermal mucin deposition. Pretibial myxedema is seen in 1% to 4% of patients with Graves’ disease and, less commonly, in patients with autoimmune thyroiditis.
Fatourechi V: Pretibial myxedema: pathophysiology and treatment options,
Am J Clin Dermatol 6(5):295–309, 2005.
