How do you treat cutaneous sporotrichosis?

Itraconazole (100 to 200 mg/day) for 4 weeks after clinical cure is the treatment of choice for lymphocutaneous, fixed cutaneous, and disseminated cutaneous sporotrichosis, with a success rate of 90% to 100%. Terbinafine (1000 mg/ day) is second-line treatment, and because potassium iodide (SSKI) is less costly than other agents, it is still recommended, especially in developing-world epidemics. Fluconazole (200 mg/day) and local hyperthermia have also been shown to be effective. Children may be safely treated with itraconazole.

Bustamante B, Campos PE: Sporotrichosis: a forgotten disease in the drug research agenda, Expert Rev Anti Infect Ther 2(1):85–94, 2004.