How does one treat lichen sclerosus?

The most widely accepted first-line treatment is use of a high-potency topical corticosteroid, most commonly clobetasol proprionate. Other less common therapies used for recalcitrant LS include intralesional corticosteroids, retinoids, oral potassium para-aminobenzoate, chloroquine, tacrolimus/pimecrolimus, cyclosporine, and photodynamic therapy with topical 5-aminolevulinic acid. LS in children often will resolve at the time of puberty.

Smith YR, Haefner HK: Vulvar lichen sclerosus: pathophysiology and treatment, Am J Clin Dermatol 5:105–125, 2004.