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| Fig. 61.2 Vitiligo showing characteristic total depigmentation with evidence of atrophy. Notice the typical scalloped margins. (Courtesy of Fitzsimons Army Medical Center teaching files.) |
Yes. Biopsy of the affected site can aid in differentiating lichen sclerosus from other disorders, such as vitiligo (Fig. 61-2) and lichen planus. Hyperkeratotic, ulcerated, or nodular lesions should be sampled to rule out vulvar intraepithelial neoplasia (VIN) or squamous cell carcinoma of the vulva. The risk of LS becoming malignant is 4% to 6%.
