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| Fig. 43.4 Multiple, small, skin-colored papules in a patient with eruptive collagenomas. |
Connective tissue nevi usually do not produce problems, although large lesions may be distressing to the patient for cosmetic reasons. Other patients may become concerned because numerous collagenomas (eruptive collagenomas) develop over a short period of time (Fig. 43-4). However, some of these nevi serve as cutaneous markers for other systemic syndromes. Collagenomas called shagreen patches are frequently seen in patients with tuberous sclerosis. Multiple connective tissue nevi called dermatofibrosis lenticularis disseminata are composed primarily of elastic fibers and are the cutaneous marker for Buschke-Ollendorff syndrome. Buschke-Ollendorff syndrome is an autosomal dominant disorder that presents with osteopoikilosis of the bones and connective tissue nevi.
