If one of my relatives has psoriasis, what is the chance that I will get psoriasis? Questionnaire-based studies reveal that almost 5% of first-degree relatives of psoriasis patients also have psoriasis, compared to 1.2% of relatives of nonpsoriatic spouses of probands. If a sibling has psoriasis, other siblings have a 16% incidence if one parent has psoriasis and a 50% chance if both parents are affected. Twin studies indicate that if one twin has psoriasis, the other twin is similarly affected in 20% of dizygotic pairs and in 73% of monozygotic pairs. The absence of 100% concordance in monozygotic twins (who have identical genetic material) indicates that environmental factors also contribute to the expression of psoriasis. |
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