Cyclophosphamide (Cytoxan)- Nitrogen mustard derivative; cell cycle DNA cross-linkages at any point in cycle
- SE: teratogenicity, ↑ lymphoma risk, ↑ leukemia risk, ↑ bladder cancer risk, ↑ SCC risk, bone marrow suppression, hemorrhagic cystitis (mesna decreases toxicity), azoospermia, pulmonary fibrosis, alopecia, hyperpigmentation of skin/nails
- Treatment of choice for Wegener’s granulomatosis
- Pregnancy category D
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