Topical Glucocorticoids

• Topical form: inhibits epidermal mitosis and DNA synthesis, ↓ collagen cross-linking
• Vasoconstriction directly proportional to anti-inflammatory potency of agent
• SE: atrophy, striae, acneiform eruption, hypertrichosis, hypopigmentation
• Tachyphylaxis: efficacy of topical lost over time; structurally different steroid required
• Pregnancy category C