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| Fig. 46.5 Lymphomatoid papulosis. The lesions occur in crops and self-heal. (Courtesy of the Fitzsimons Army Medical teaching files.) |
This chronic recurrent skin eruption is characterized by papules and/or nodules that frequently crust or ulcerate and selfheal, often with atrophic scars (Fig. 46-5). There are three histopathologic types. Type A has large Reed-Sternberg–like cells, which are often CD30 (Ki-1) positive. Type B has moderately large atypical cells with cerebriform nuclei similar to the cell type found in mycosis fungoides. These cells are usually CD30 negative. Type C is composed of sheets of cells that resemble the cells of anaplastic T-cell lymphoma. About 15% to 20% of patients with lymphomatoid papulosis will develop a lymphoma.
El Shabrawi-Caelen L, Kerl H, Cerroni L: Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C,
Arch Dermatol 140:441–447, 2004.
