and is a nomenclature for identification of specific cell surface antigens defined by monoclonal antibodies. The procedure can be applied to both formalin-fixed and frozen tissue. It is very helpful in identifying subpopulations of T- and B-cell lymphocytes (Table 46-2).
| Table 46-2. Cells Marked by CD Antigens |
| | CD2 | | T cells (E rosette receptor) |
| | CD3 | | T-cell receptor |
| | CD4 | | Helper T cells |
| | CD5 | | Mature thymocytes, some B-cell subsets |
| | CD7 | | T cells, natural killer (NK) cells |
| | CD8 | | T cells, NK cells |
| | CD10 | | Pre-B cells, lymphoblastic leukemia cells |
| | CD14 | | Monocytes |
| | CD15 | | Reed-Sternberg cells, myeloid cells |
| | CD19 | | Pan-B cells |
| | CD20 | | Pan-B cells, dendritic cells |
| | CD21 | | Receptor for complement 2 and Epstein-Barr virus |
| | CD23 | | Activated B cells, monocytes, eosinophils, and platelets |
| | CD25 | | Activated T and B cells, monocytes (interleukin-2 receptor) |
| | CD30 | | Ki-1–related cells, Reed-Sternberg cells, T-cell NHL |
| | CD34 | | Lymphoid and myeloid precursor cells |
| | CD43 | | T cells, myeloid cells |
| | CD45 | | Leukocytes |
| | CD45R | | T cells, myeloid cells |
| | CD56 | | NK cells |
| | CD74 | | HLA-invariant chain |
| | CD75 | | Follicular center cells |
| | CD, Cluster of differentiation; HLA, histocompatibility locus antigen; NHL, non-Hodgkin’s lymphoma. |
