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| Fig. 19.2 Appropriate wedge biopsy technique for panniculitis as shown in a case of erythema nodosum. The biopsy extends from the epidermis to a wide base in the subcutaneous fat. (Courtesy of Kenneth E. Greer, MD.) |
The specimen should be obtained from the most fully developed (central) portion of the lesion (Fig. 19-2). It is absolutely critical that the biopsy be deep enough to incorporate subcutaneous fat. Incisional biopsies that include a generous horizontal expanse of subcutis are preferred to small punch biopsies.
