What is pompholyx?

Pompholyx, from the Greek word for “bubble,” accounts for up to 20% of hand dermatitis cases. It also has been called dyshidrotic eczema, even though no definite relationship to sweating has been demonstrated. Patients develop crops of clear, deep-seated, tapioca-like vesicles on the palms and sides of the fingers in 80% of cases (Fig. 8-2). Another 10% also have sole involvement, whereas the remaining 10% have only sole involvement. Erythema is often absent, and heat and prickling sensations may precede attacks. Nails may become dystrophic. The cause is unknown, but it may be a manifestation of atopic dermatitis and is exacerbated by stress in many patients.