Zygomycosis (Mucormycosis) | Figure 4.34
A: Mucormycosis
(Courtesy of Dr. Paul Getz)
B: Rhinosporidiosis*
C: Rhinosporidiosis*
*Reproduced with permission
from: Kumari R, Laxmisha C,
Thappa, DM. Disseminated
cutaneous rhinosporidiosis.
Dermatol Online J.
Mar 2005;11 (1) :19
D: Protothecosis
(Courtesy of Sandra Arduin,
Michigan Department of
Community Health) |
| Figure 4.33
A: Cryptococcus neoformans
(Courtesy of Doctor Fungus,
www.doctorfungus.org)
B: Mucormycosis
(Courtesy of Dr. Paul Getz)
C: Mucor spp.*
D: Rhizopus spp .*
*Courtesy of Sandra Arduin,
Michigan Department of
Community Health |
(Figures 4.33B–D and 4.34A) - Absidia spp. , Rhizopus spp. , Mucor spp. (most common); ubiquitous in nature (soil, fruits, decaying vegetation); risk factors include neutropenia, diabetes mellitus, metabolic acidosis, severe burns, immunosuppression
- Transmission typically via inhalation
- Rhinocerebral infection: typically seen in diabetic patients with nasal or sinus infection under poor control → dissemination or rapid contiguous spread causing indurated necrotic plaque, facial edema, orbital cellulitis, bloody nasal discharge, and cavernous sinus thrombosis
- Local cutaneous: typically secondary infection of a burn, less common catheter-associated infections
- Histology: large ribbon-like hyphae with 90° branching (wider than Aspergillus), ring-shaped on cross section, tend to invade blood vessels and form thrombi
- Culture: rapid cotton candy-like growth
- Treatment: amphotericin B and debridement
|
