Necrotizing Fasciitis- Rapidly progressive necrosis of subcutaneous tissue and fascia due to GAS, but typically mixed infection with 30% mortality rate
- Risk factors include advanced age, diabetes, peripheral vascular disease, and/or history of alcohol abuse
- Presents as tender, erythematous tense plaques recalcitrant to antibiotics and progresses at an alarming rate → necrosis of fascia and fat renders watery foul-smelling fluid
- Treatment: extensive surgical debridement
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