Congenital Ichthyosiform Erythroderma (Nonbullous CIE)- AR (some AD), TGM1 gene, few ALOXE3 or ALOX12B gene mutation (encode lipoxygenase 3 and 12R-lipoxygenase, respectively)
- Presents at birth with collodion membrane → generalized erythroderma and persistent scaling, flexures involved, PPK; no improvement with age
- Associated scarring alopecia, ectropion, nail dystrophy (similar to LI but milder), heat intolerance
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