Neurofibroma | Figure 2.13 A: Neurofibromas (Courtesy of Dr. Paul Getz) B: Connective tissue nevus (Reprint from Laxer RM, ed. The Hospital for Sick Children: Atlas of Pediatrics. Philadelphia, PA: Current Medicine, 2005) C: Connective tissue nevus (Courtesy of Dr. Paul Getz) D: Infantile digital fibroma (Reprint from Burgdorf WH, Plewig G, Wolff HH, Landthaler M, eds. Braun-Falco’s Dermatology. 3rd ed. Heidelberg: Springer; 2009) |
Presents as skin-colored, soft or rubbery papulonodule with positive “buttonhole” sign (easily invaginated) - Commonly seen as solitary lesion; multiple lesions associated with neurofibromatosis
- Plexiform NF considered pathognomonic for NF1, malignant transformation in 2–13%
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