Neurofibroma

  • Figure 2.13 A: Neuroflbromas (Courtesy of Dr. Paul Getz) B: Connective tissue nevus (Reprint from Laxer RM , ed. The Hospital for Sick Children: Atlas of Pediatrics. Philadelphia, PA: Current Medicine, 2005) C: Connective tissue nevus (Courtesy of Dr. Paul Getz) D: Infantile digital flbroma (Reprint from Burgdorf WH, Plewig G, Wolff HH, Landthaler M, eds. Braun-Falco’s Dermatology. 3rd ed. Heidelberg: Springer; 2009)
    Figure 2.13
    A: Neurofibromas
    (Courtesy of Dr. Paul Getz)
    B: Connective tissue nevus
    (Reprint from Laxer RM, ed.
    The Hospital for Sick Children:
    Atlas of Pediatrics. Philadelphia,
    PA: Current Medicine, 2005)
    C: Connective tissue nevus
    (Courtesy of Dr. Paul Getz)
    D: Infantile digital fibroma
    (Reprint from Burgdorf WH,
    Plewig G, Wolff HH, Landthaler
    M, eds. Braun-Falco’s
    Dermatology. 3rd ed.
    Heidelberg: Springer; 2009
    )
    Presents as skin-colored, soft or rubbery papulonodule with positive “buttonhole” sign (easily invaginated)
  • Commonly seen as solitary lesion; multiple lesions associated with neurofibromatosis
  • Plexiform NF considered pathognomonic for NF1, malignant transformation in 2–13%