Which diseases have been treated with extracorporeal photopheresis?

Photopheresis is approved for the treatment of cutaneous T-cell lymphoma (mycosis fungoides). It is most effective in the erythrodermic variants (Sézary syndrome) that involve >25% of the body surface. The response rate in this group of patients is about 64%. Photopheresis, as a form of immunotherapy, has also been tried on other T cell–mediated diseases, such as pemphigus vulgaris, chronic Lyme arthritis, psoriatic arthritis, and progressive systemic sclerosis.

Armus S, Keyes B, Cahill C, et al: Photophoresis for the treatment of cutaneous T-cell lymphoma, J Am Acad Dermatol 23:898–902, 1990.