How do you treat MCC?

Wide local excision with surgical margins up to 3.0 cm has been recommended. In cosmetically sensitive areas, Mohs surgery may be helpful, although research is limited. Other considerations at the time of surgery include assessment of regional lymph nodes (lymph node dissection) and irradiation. Chemotherapy is used for nodal, metastatic, and recurrent MCC, and common agents used are cyclophosphamide, anthracyclines, and cisplatin. Local recurrences occur in 40% of patients.

Eng TY, Naguib M, Fuller CD, et al: Treatment of recurrent Merkel cell carcinoma: an analysis of 46 cases, Am J Clin Oncol 27:576– 583, 2004.