What stage follows untreated secondary syphilis? The mucocutaneous lesions of secondary syphilis usually heal without scarring in 2 to 10 weeks, although hyperpigmentation or hypopigmentation may persist. Following the resolution of secondary syphilis, patients enter the latent stage of infection. During this stage, approximately one fourth of patients experience relapsing secondary lesions. Most relapses occur in the first year, but these may occur for up to 5 years. |
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