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Photosensitive Dermatitis

»What is the definition of photosensitivity?
»What is the difference between a phototoxic reaction and a photoallergic reaction?
»What is the clinical appearance of a photodistributed eruption?
»Name some of the most common topical phototoxic and photoallergic agents and their action spectrums.
»Name some of the most common systemic phototoxic and photoallergic agents and their action spectrums.
»Give some examples of unique phototoxic reactions.
»What are some scenarios in which the skin may be more sensitive to ultraviolet radiation?
»What are the important questions to ask a patient with suspected photosensitivity?
»What are the most common causes of photosensitive dermatoses?
»What is persistent light reactivity?
»What is polymorphous light eruption (PMLE)?
»How is PMLE diagnosed?
»How is PMLE treated?
»What is actinic prurigo?
»What is solar urticaria?
»Discuss the differential diagnosis of photodermatoses in infants or young children.
»How do hydroa aestivale and hydroa vacciniforme differ?
»Which porphyrias are associated with photodermatoses?
»Describe the cutaneous changes in porphyria cutanea tarda.
»What causes porphyria cutanea tarda?
»How is porphyria cutanea tarda diagnosed?
»How is variegate porphyria distinguished from porphyria cutanea tarda?
»What treatments are used in porphyria cutanea tarda?
»What are the cutaneous findings in erythropoietic protoporphyria?
»How is a diagnosis of erythropoietic protoporphyria made?
»What treatments are used in erythropoietic protoporphyria?
»Do any other medical problems occur in patients with erythropoietic protoporphyria?
»Name some other photorelated disorders.

 
 
 

What is polymorphous light eruption (PMLE)?


Polymorphous light eruption. Erythematous, scaly plaque on the lateral neck, which tended to recur each spring.
Fig. 17.4 Polymorphous light eruption. Erythematous, scaly plaque on the lateral neck, which tended to recur each spring.
PMLE is a common, chronic photoeruption that typically begins in the first three decades of life. There may be a positive family history of sunlight sensitivity. Patients characteristically report the onset of skin disease beginning with sun exposure in spring or early summer. Patients sometimes demonstrate gradual improvement with continuing sun exposure, a phenomenon termed “hardening.” The specific skin lesions of PMLE may be of numerous (polymorphous) types, but one or two morphologic types usually predominate in individual patients. These include erythematous macules, patches, papules, plaques (Fig. 17-4), and vesicles and bullae. Lesions are photodistributed, often on the face and neck, chest, and dorsal arms and hands. The lips may also be involved. The etiology of PMLE is unknown, and most patients with PMLE do not have antinuclear antibodies. Patients with PMLE have been reported to be sensitive to ultraviolet B (UVB), ultraviolet A (UVA), or both. Synonyms include benign summer light eruption and juvenile spring eruption.

Dummer R, Ivanova K, Scheidegger EP, Burg G: Clinical and therapeutic aspects of polymorphous light eruption, Dermatology 207:93–95, 2003.