»	What is meant by “granulomatous diseases of the skin”?
»	Explain the role of histiocytes in granulomas.
»	What is the difference between an immune granuloma and a foreign body granuloma?
»	List some common granulomatous diseases that affect the skin.
»	Can granulomas be recognized clinically?
»	How do endogenous “foreign” bodies cause granulomas?
»	What are the sources of the exogenous foreign body agents?
»	Do cosmetic fillers ever produce foreign body granulomas?
»	Can the cause of a foreign body reaction be diagnosed histologically?
»	What is sarcoidosis?
»	How often is the skin involved in sarcoidosis?
»	Describe the specific cutaneous findings in sarcoidosis.
»	What is lupus pernio?
»	Describe the nonspecific cutaneous lesions of sarcoidosis.
»	Does sarcoidosis ever present in the skin without extracutaneous involvement?
»	What is Löfgren’s syndrome?
»	What is Heerfordt’s syndrome?
»	How should cutaneous sarcoidosis be treated?
»	What is the typical presentation of granuloma annulare?
»	Do any systemic associations occur with granuloma annulare?
»	What is the typical course of granuloma annulare?
»	How is granuloma annulare treated?
»	What is actinic granuloma?
»	Are rheumatoid nodules really a granulomatous disorder?
»	Where do rheumatoid nodules typically occur?
»	What causes rheumatoid nodules?
»	What is accelerated nodulosis?
»	Are rheumatoid nodules specific for rheumatoid arthritis?
»	Do patients with lupus miliaris disseminatus faciei have lupus erythematosus?

List some common granulomatous diseases that affect the skin.

See Table 13-1.

Table 13-1. Agents and Diseases That Can Produce Granulomas
Infectious Agents
	Fungi Blastomycosis Candidiasis Chromomycosis Coccidioidomycosis Cryptococcosis Histoplasmosis Sporotrichosis	Bacteria Actinomycosis Cat scratch fever Granuloma inguinale (donovanosis) Mycobacterial infections Nocardiosis Syphilis Tularemia	Miscellaneous Infections Leishmaniasis Protothecosis (algae infection)
Foreign Body Agents
	Exogenous Aluminum Cosmetic fillers Hair Insect parts Paraffin Silica Splinters Starch Sutures Talc Tattoo pigment	Endogenous Bone Calcium Cholesterol Keratin Hair Sebum Urate crystals	Miscellaneous Diseases Actinic granuloma Crohn’s disease Granuloma annulare Granulomatous cheilitis Granulomatous rosacea Lupus miliaris disseminatus faciei Necrobiosis lipoidica Rheumatoid nodule Sarcoidosis