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Vesiculobullous Disorders

»What is the difference between a vesicle and a bulla?
»How are the bullous diseases defined?
»What things cause vesicles and bullae?
»How do you approach a patient who presents with an acute onset of a vesiculobullous eruption?
»Which skin findings are helpful in evaluating a patient with blisters?
»Do particular vesiculobullous diseases occur in characteristic distributions?
»Which tests are most useful in evaluating vesiculobullous diseases?
»How should a skin biopsy of a vesiculobullous eruption be performed?
»When are special tests necessary to diagnose blistering diseases of the skin?
»How are specimens obtained for direct immunofluorescence?
»For which vesiculobullous diseases are indirect immunofluorescence helpful?
»List the most common blistering diseases due to external agents.
»Name examples of drugs that can cause vesiculobullous eruptions.
»What is epidermolysis bullosa?
»Describe the other genetic blistering diseases.
»List the vesiculobullous diseases caused by metabolic disorders.
»Describe the clinical findings in bullous diabeticorum.
»What is the cause of pellagra?
»What is the difference between porphyria cutanea tarda and pseudoporphyria?
»What are the necrolytic erythemas?
»What is the difference between bullous pemphigoid and cicatricial pemphigoid?
»How do pemphigus vulgaris and pemphigus foliaceus differ?
»Linear IgA bullous dermatosis occurs in two different clinical situations. What are they?
»Describe the clinical findings in dermatitis herpetiformis.
»Does herpes gestationis have anything to do with herpes viruses?
»What is bullous systemic lupus erythematosus?
»What is epidermolysis bullosa acquisita?

 
 
 

Does herpes gestationis have anything to do with herpes viruses?

No. Herpes gestationis, also called gestational pemphigoid, is a rare, autoimmune blistering disease with IgG autoantibodies directed against BP180 (type XVII collagen), which is an important component of the hemidesmosome. It is seen in pregnant women, typically beginning in the second trimester. Lesions often begin in the periumbilical area and may initially be urticarial. Later, tense vesicles and bullae develop, which may resemble bullous pemphigoid. The disease may flare after delivery and may recur in subsequent pregnancies. The pregnancy should be monitored, because premature births as well as small-forgestational-age infants have occurred in some patients. The diagnosis is made from clinical findings, routine histology of an early blister or urticarial lesion, and direct and indirect immunofluorescence tests.