Does herpes gestationis have anything to do with herpes viruses? No. Herpes gestationis, also called gestational pemphigoid, is a rare, autoimmune blistering disease with IgG autoantibodies directed against BP180 (type XVII collagen), which is an important component of the hemidesmosome. It is seen in pregnant women, typically beginning in the second trimester. Lesions often begin in the periumbilical area and may initially be urticarial. Later, tense vesicles and bullae develop, which may resemble bullous pemphigoid. The disease may flare after delivery and may recur in subsequent pregnancies. The pregnancy should be monitored, because premature births as well as small-forgestational-age infants have occurred in some patients. The diagnosis is made from clinical findings, routine histology of an early blister or urticarial lesion, and direct and indirect immunofluorescence tests. |
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