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Vesiculobullous Disorders

»What is the difference between a vesicle and a bulla?
»How are the bullous diseases defined?
»What things cause vesicles and bullae?
»How do you approach a patient who presents with an acute onset of a vesiculobullous eruption?
»Which skin findings are helpful in evaluating a patient with blisters?
»Do particular vesiculobullous diseases occur in characteristic distributions?
»Which tests are most useful in evaluating vesiculobullous diseases?
»How should a skin biopsy of a vesiculobullous eruption be performed?
»When are special tests necessary to diagnose blistering diseases of the skin?
»How are specimens obtained for direct immunofluorescence?
»For which vesiculobullous diseases are indirect immunofluorescence helpful?
»List the most common blistering diseases due to external agents.
»Name examples of drugs that can cause vesiculobullous eruptions.
»What is epidermolysis bullosa?
»Describe the other genetic blistering diseases.
»List the vesiculobullous diseases caused by metabolic disorders.
»Describe the clinical findings in bullous diabeticorum.
»What is the cause of pellagra?
»What is the difference between porphyria cutanea tarda and pseudoporphyria?
»What are the necrolytic erythemas?
»What is the difference between bullous pemphigoid and cicatricial pemphigoid?
»How do pemphigus vulgaris and pemphigus foliaceus differ?
»Linear IgA bullous dermatosis occurs in two different clinical situations. What are they?
»Describe the clinical findings in dermatitis herpetiformis.
»Does herpes gestationis have anything to do with herpes viruses?
»What is bullous systemic lupus erythematosus?
»What is epidermolysis bullosa acquisita?

 
 
 

Describe the clinical findings in bullous diabeticorum.

Bullous diabeticorum is characterized by tense bullae that arise spontaneously on the distal extremities in patients with both insulin-dependent and non–insulin-dependent diabetes. The course is chronic and recurring. The diagnosis is made by the clinical findings and skin biopsy. Although the histologic findings are not specific, they may help to rule out other bullous diseases.