| | Artecoll/Artefill Polymethyl-dismethacrylate microspheres in denatured bovine collagen | | Indicated for the correction of facial rhytids and scars and lip augmentation [10]. It is useful especially for correcting depressions and deeper creases [18, 28]. FDA approval pending US clinical testing | | Injected into the junction of the dermis and the subcutaneous space using a tunneling technique in which the material is injected as the needle is withdrawn.Use of a small needle often gives a more even result.Overcorrection is not recommended, and it may take several sessions to obtain the desired correction [18, 28]. Repeat treatment every 6 weeks until adequate augmentation [10]. It is used for the correction of moderate- depth lines and depressions [4]. An allergy test is required because bovine collagen is used as a carrier [18, 28] | | May cause inflammation, induration, discoloration, ulceration, migration, and formation of granulomas [10, 18, 28] |
| | Silskin AdatoSil 5000 Silikon 1000 Silicone Oil | | FDA-approved for ocular medical purposes. The FDA has not approved silicone oil for cosmetic use in the USA.However, it is used in Europe,Mexico, and some parts of Canada for cosmetic purposes, and offlabel use within the USA does occur. It is used for the correction of moderate depth lines and depressions. Silicone has been approved by the FDA for use in treatment of retinal detachment and/or hemorrhage [4] | | Microdroplets of silicone oil are dispersed within the dermal tissues, and fibrosis around these droplets localizes the material and provides “bulk.”No allergy testing is required as silicone oil in small amounts is well tolerated [4] | | Risks of infection, generally due to granuloma formation as the silicone becomes encapsulated as a foreign body in a chronic inflammatory reaction.Several other disadvantages exist as well, including the risk of possible migration to other organs and the lymph nodes [4] |
