How is DFSP treated?

Adequate local excision is the treatment of choice. Mohs micrographic surgery affords the highest cure rates (>95%). Patients with locally aggressive tumors that are not resectable or with metastatic disease are most commonly treated with imatinib mesylate, which targets a specific translocation between chromosomes 17 and 22 that is found in most cases of DFSP.

Llombart B, Sanmartin O, López-Guerro JA, et al: Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB) study with therapeutic implications, Histopathology 54:860–872, 2009.

Wacker J, Khan-Durani B, Hartschuh W: Modified Mohs micrographic surgery in the therapy of dermatofibrosarcoma protuberans: analysis of 22 patients, Ann Surg Oncol 11:438–444, 2004.