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Vasculitis

»	How are vasculitic disorders defined and classified?
»	Are there specific serologic markers for any of these vasculitic disorders?
»	What is a leukocytoclastic vasculitis?
»	What are some important precipitating causes of small vessel leukocytoclastic vasculitis?
»	What is Henoch-Schönlein purpura?
»	What is the mnemonic that can help remember the clinical features of Henoch-Schönlein purpura?
»	What is “acute hemorrhagic edema of infancy” and how does it differ from Henoch-Schönlein purpura?
»	What are cryoglobulins?
»	Can cryoglobulins produce a vasculitis?
»	What is Churg-Strauss syndrome?
»	What were those features again?
»	What is Wegener’s granulomatosis?
»	What are the features needed to establish a diagnosis of Wegener’s granulomatosis.
»	Is there an easy way to remember these diagnostic criteria?
»	List the cutaneous findings in Wegener’s granulomatosis.
»	Wegener’s granulomatosis and Churg-Strauss syndrome seem very similar. How do you distinguish between them?
»	What forms of treatment are available for Wegener’s granulomatosis and Churg-Strauss syndrome?
»	What are the major organs involved in classic (systemic) polyarteritis nodosa (PAN)?
»	How is classic polyarteritis nodosa different from Kawasaki disease?
»	What is primary cutaneous polyarteritis nodosa?
»	What is the primary difference between microscopic polyangiitis and PAN?
»	What is the difference between giant cell (temporal) arteritis and Takayasu arteritis?
»	What is erythema elevatum diutinum?
»	Are there any other obscure disorders known to dermatologists, but little known to other subspecialties, that could be classified as vasculitis?

What are cryoglobulins?

Cryoglobulins are abnormal circulating IgG and IgM immunoglobulins that precipitate at low temperatures and redissolve at 37° C. Cryoglobulins are frequently found in patients with paraproteinemias, such as multiple myeloma and macroglobulinemia. Mixed cryoglobulinemia, with more than one antibody class involved, has been reported in systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, and hepatitis B and C infection.

Trejo O, Ramos-Casals M, Garcia-Carrasco M, et al: Cryglobulinemia: study of etiologic factors and clinical and immunologic features in 443 patients from a single center, Medicine (Baltimore) 80:252–262, 2001.