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Mechanobullous Disorders

»	What are the mechanobullous disorders?
»	Do all of the blisters that form in EB develop in the same layer of the skin?
»	How is EB classified, and what are the major modes of inheritance?
»	Describe the clinical findings in EB simplex.
»	Is the cause of EB simplex known?
»	What are the clinical findings in junctional EB?
»	Is the cause of junctional EB known?
»	What are the clinical findings in dystrophic EB?
»	Is the cause of dystrophic EB known?
»	What is Kindler’s syndrome?
»	Can a definitive diagnosis of the various EB types be made on clinical presentation?
»	Are there any treatments for the mechanobullous disorders?
»	Are prenatal diagnostic techniques useful for this group of disorders?

Are prenatal diagnostic techniques useful for this group of disorders?

Fetoscopy with fetal skin biopsy has been the primary method of prenatal diagnosis for EB and other inherited skin diseases. More recently, it has been found that fetal DNA can be obtained as early as 10 weeks estimated gestational age (EGA) from chorionic villi or 12 weeks EGA from amniotic fluid.

Fassihi H, Ashton GH, Denyer J, et al: Prenatal diagnosis of Herlitz junctional epidermolysis bullosa in nonidentical twins, Clin Exp Dermatol 30:180–182, 2005.