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Atypical Fibroxanthoma (AFX)

Figure 5.15 A: DFSP, chest (Courtesy of Dr. Sophie M. Worobec) B: DFSP (Reprint from Markman M, ed. Atlas of Cancer. Philadelphia: Current Medicine Inc; 2002) C: Atypical fibroxanthoma (Reprint from Bolognia JL, Rapini R, Jorrizo JL. Dermatology. 2nd ed. St. Louis, MO: Mosby; 2008)

Figure 5.15
A: DFSP, chest
(Courtesy of Dr. Sophie
M. Worobec)
B: DFSP
(Reprint from Markman M,
ed. Atlas of Cancer.
Philadelphia:
Current Medicine Inc; 2002)
C: Atypical fibroxanthoma
(Reprint from Bolognia JL,
Rapini R, Jorrizo JL.
Dermatology. 2nd ed.
St. Louis, MO: Mosby; 2008)

(Figure 5.15C)
  • Superficial variant of MFH; low-grade sarcoma typically in elderly patients with small risk of metastasis
  • Presents with red nodule or plaque on sun-damaged skin with frequent ulceration
  • Histology: cellular proliferation in dermis consisting of bizarre spindle cells, epithelioid cells, and multinucleated giant cells, ± foamy cells, many atypical mitoses and severe pleomorphism seen, prominent solar elastosis

 

 

 

 

 

 

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