Lentigines- Presents as brown macules with increased number of melanocytes; no relationship to sunlight
- Multiple lentigines may be associated with the following:
| | | | | | | | LEOPARD Syndrome | | AD, PTPN11 gene, café-noir macules, EKG changes, ocular hypertelorism, pulmonary stenosis, abnormal genitalia, growth retardation, deafness | | | Carney Complex
(LAMB or NAME syndrome) | | AD, PRKAR1A gene, psammomatous melanotic schwannomas, cardiac/cutaneous myxomas, blue nevi, endocrine overactivity | | | Peutz–Jeghers Syndrome | | AD, STK11 gene (serine threonine kinase), mucocutaneous (oral/acral) lentigines, intestinal polyposis, ± intussusception, various malignancies | | | Laugier–Hunziker Syndrome | | Mucocutaneous lentigines, longitudinal melanonychia, genital melanosis | | | Bannayan–Riley– Ruvalcaba Syndrome | | AD, PTEN gene, penile > vulvar lentigines, lipomas, hemangiomas |
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