| | Radiesse/Radiance Synthetic calcium hydroxylapatite microspheres suspended in polysaccharide gel | | FDA-approved only for vocal cord augmentation and urinary incontinence [17] | | Injected into the subdermis. Intradermal placement can result in swelling, pain, persistent erythema, and visible or palpable granules. Slight over-correction is recommended. Massage area once the injection is completed. Repeat injections 1–3 months after the initial treatment. Skin testing is mandatory [8, 10] | | Pruritus or hypertrophic-scarring can occur and implantation site allergic reactions and granulomas aqueous may occur. Removal of calcium hydroxylapatite is not easy. If excessive collagen production is observed, it can be dealt with using corticosteroid injections [4] |
