How are the amide and ester anesthetics metabolized? The amides are metabolized by hepatic microsomal enzymes. These drugs should therefore be used with great caution in patients with underlying liver disease. The esters are metabolized by plasma pseudocholinesterase, to form paraaminobenzoic acid (PABA) and diethylamino ethanol, both of which are excreted by the kidneys. |
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