| High risk
Prosthetic cardiac valves History of previous bacterial endocarditis Complex cyanotic congenital heart disease (i.e., transposition of great vessels) Surgical systemic pulmonary shunts or conduits
Moderate risk
Mitral valve prolapse (MVP) with valvular regurgitation and/or thickened leaflets Hypertrophic cardiomyopathy Acquired valve dysfunction (rheumatic heart disease) Certain other congenital cardiac malformations Orthopedic prosthesis (first 6 months postop) | | | Negligible risk per AHA
Isolated secundum atrial septal defect Ventricular septal defect Patent ductus arteriosus (without residua beyond 6 months) Physiologic “innocent” heart murmur MVP without valvular regurgitation Cardiac pacemakers, cardiac stents, or implanted defibrillators, CABG Previous rheumatic fever (no valvular dysfunction) |