Leiomyosarcoma

  • Superficial malignant smooth muscle tumor
  • Presents as solitary or multiple deep nodules with rapid enlargement or ulceration; predilection for head, neck, or extremities
  • Histology: ranges from well-differentiated neoplasm with resemblance to leiomyoma to poorly differentiated neoplasm with liking to atypical fibroxanthoma; more cellular with atypia and mitoses than in leiomyoma
  • Prognosis excellent; dermal lesions rarely metastasize but subcutaneous lesions may (up to 30–40% of cases)
  • Treatment: complete excision