Candidiasis- Candida spp.
| | | | | | | | C. albicans | | Most common species | | | C. glabrata | | Fungemia in compromised patients, fluconazole-resistant | | | C. parapsilosis | | Chronic paronychia, endocarditis in IV drug users | | | C. tropicalis | | Frequent dissemination to skin | | | C. dubliniensis | | Frequent dissemination to skin | | | C. krusei | | Endocarditis in IV drug users |
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- Common opportunistic infection
- Varying presentations in immunocompromised patients: candidal folliculitis, candidal esophagitis, neonatal candidiasis, and candidemia
- Cutaneous findings for candidemia: tiny pink macules and papules → evolve into pustules → papulonecrotic eschars and purpura
- Histology: pseudohyphae and budding yeast
- Treatment: amphotericin B, ketoconazole, fluconazole, itraconazole, caspofungin
- Of note, cycloheximide partially inhibits C. tropicalis and strongly inhibits C. parapsilosis
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